Welcome to the XVIth IPCC page.

On this page, you will find:

• General Information
• Contact Information
• Official Scientific Program

General Information:

Contact Information:

Dr. Roger Bowers, California State University, Department of Biology, 5151 State University Drive, Los Angeles, CA 90032 USA.
- - - FAX: 213/343-6451; phone: 213/343-2081

Dr. Alistair Cochran, UCLA Medical Center, Anatomic Pathology, 13-344 CHS, Los Angeles, CA 90024 USA
- - - FAX: 310/206-5178; Phone: 310/825-2743

Tuesday, October 29, 1996

3:00-7:00 pm Pre-registration/View Exhibits
7:00-10:00 pm Welcome Reception: Fashion Show: "Safe and Sexy in the Sun"

Wednesday, October 30, 1996

Accompanying Guests:

9:00 - 11:00 am Buffet Breakfast

10:00 - 11:00 am Orientation

11:00 am - 6:00 pm Group Activity

Meeting Participants:

7:00-8:00 am Registration / Continental Breakfast / View Exhibits

8:00-8:05 am Welcome: Chairman, Frank L Meyskens, Jr

Introduction: Laurel Wilkening, Chancellor, University of California, Irvine

8:05-8:35 am Special Lecture, F Sherwood Rowland, Nobel Laureate, 1995, Chemistry

#1 "Stratospheric Ozone Depletion and Increased UVB at Earth's Surface"

Symposium I: Economic and Societal Implications of Melanin and Melanogenesis

Co-Chairs: Mac Hadley, JF Dore, Shosuke Ito

8:35-9:00 am Keynote Speaker

#2 Miles Chedekel: "Commercial Applications of Melanins and Melanogenesis"

9:00-10:30 am Invited and Competitive Abstract Speakers

#3 Genji Imokawa: "The role of endothelin-1 in epidermal hyperpigmentation and signaling mechanism of mitogenesis and melanogenesis"

#4 P Autier: "Pigmented lesions of the skin in children, sunscreen use and exposure to sunlight"

#5 Giuseppe Prota: "Cosmetic applications of melanins and melanogenesis: status quo and prospects"

10:30-11:00 am Break

11:00-12:30 pm Workshop A: Extracutaneous Melanin, Melanocytes and Melanogenesis

Chair and Overview: Ralf-Uwe Peter, Co-Chairs: Helene Hill and Tadahisa Seikai

Invited and Competitive Abstract Speakers

#6 Helene Z Hill: "Melanin--the two-edged sword?"

#7 Tadahisa Seikai: "Normal and abnormal pigmentation processes of flatfish in relation to larval metamorphosis"

#8 Johan Stjernschantz: "Prostaglandin-induced increase of iridial pigmentation"

#9 Adelina Zuasti: "Ultrastructure and histochemistry of the pigment cells in the stria vascularis of the mesocricetus auratus"

Workshop B: Dynamics of Invertebrate Pigment Cells

Chair and Overvew: Sumiko Negishi, "Regulation of invertebrate pigmentation", CoChairs: K Ranga Rao, Detlef Buckmann

Invited and Competitive Abstract Speakers

#10 Luiz Nery: "Cellular signalling in the crustacean erythrophore"

#11 Detlef Buckmann: "Hormonal control and pattern formation in insect pigmentation"

#12 Y Hasegawa: "Regulation of pigment genesis in albinism"

#13 Masaaki Ashida: "The insect prophenol oxidase is a protein homologous to arthropod hemocyanin and activated through the action of a cascade triggered by microbial cell wall components"

11:00-12:00 pm Posters and Discussion #1: Melanoma Research: Basic and Applied

Frank L Meyskens, Jr, MD, Chair

11:00-12:00 pm Poster Viewing

12:00-12:30 pm Discussion

12:30-2:00 pm Lunch on your own

Symposium II: Molecular Biology of Pigment Cells

Co-Chairs: Shigeki Shibahara, Manfred Schartl, Vincent J Hearing

2:00-2:30 pm Keynote Speaker

#14 Nicolas Dracopali: "Mutations in Genes Regulating the G1 Checkpoint Account for Almost Half of Familial Melanomas"

2:30-4:00 pm Invited and Competitive Abstract Speakers

#15 Manfred Schartl: "Analysis of the molecular mechanisms leading to pigment cell transformation by the xmrk receptor tyrosine kinase of xiphophorus"

#16 Hiroaki Yamamoto: "Evolution of developmental systems of pigment cells"

#17 Kazutomo Toyofuku: "Molecular chaperone, calnexin, associates with tyrosinase, the key enzyme in melanogenesis"

#18 Dorothy C Bennett: "Cloning and mapping of a human gene sequence that promotes differentiation of mouse melanoma cells and may retard tumor development"

#19 Susan Porter: "Complex regulatory properties of the distal upstream mouse tyrosinase enhancer"

4:00-4:05 pm IFPCS / WWW: Vincent Hearing

4:05-4:15 pm Break

4:15-6:15 pm Workshop C: "Regulating Mechanisms of Melanocyte Proliferation"

Chair and Overview: Zalfa Abdel-Malek, co-Chairs: Masako Mizoguchi, Anthony Thody

Invited and Competitive Abstract Speakers

#20 Masayoshi Tachibana: "Expression of MITF induces melanocyte differentiation and haploinsufficiency of MITF causes Waardenburg Syndrome type 2A"

#21 Sheila MacNeil: "Effect of ECM proteins on melanocyte proliferation and tyrosinase activity in media of varying mitogenic potency"

#22 Anthony J Thody: "Why are melanocytes vulnerable to oxidative damage?"

#23 Maher Haddad: "Correlation of end-stage differentiation of human melanocytes with suppression of cylin D1 and induction of MITF, p21 waf-1/SDI-1 and P27 KIP-1"

#24 Anton Platz: "Evidence for UV-induction of mutations in genes related to the cell cycle G1 checkpoint control in human cutaneous melanoma"

4:15-6:00 pm Posters and Discussion #2: Melanogenesis:

John Pawelek, Chair

4:15-5:30 pm Poster Viewing

5:30-6:00 pm Discussion

5:30-7:00 pm Workshop D: Biophysics and Chemistry of Melanin

Chair and Overview: Tadeusz Sarna, Co-Chairs: Kazumasa Wakamatsu, Harold Swartz

Invited and Competitive Abstract Speakers

#25 Julian Menter: "Electron transfer and photoprotective properties of melanins in solution"

#26 Kazumasa Wakamatsu: "Usefulness of spectrophotometric and HPLC methods in measuring hair melanins"

#27 Martin G Peter: "On the redox state of enzymatically generated tyrosine melanin"

#28 Melvin Eisner: "EXAFS studies of chelated Fe sites in natural and synthetic neuromelanins"

#29 Harold M Swartz: "Implications of the interactions of melanin with reactive species"

Workshop E: Vitiligo

Chair and Overview: David Norris, "Factors which determine melanocyte survival", Co-Chairs: Karin U Schallreuter-Wood, Robert Aquaron

Invited and Competitive Abstract Speakers

#30 Wiete Westerhof: "Treatment of vitiligo with UVB (311NM) versus topical puva"

#31 James J Nordlund: "Vitiligo: an analysis of proposed etiologies"

#32 R van den Wijngaard: "Melanocyte anti-oxidant defence and immune infiltrates in vitiligo"

#33 Ram K Tripathi: "Evaluation of MITF locus linkage to human vitiligo and ostepetrosis"

#34 Alain Taieb: "In vivo and ex vivo melanocyte transplants in vitiligo: an extrinsic factor is needed to trigger the disease"

7:00 pm Adjourn - Free evening

Thursday, October 31, 1996

7:00-8:00 am Continental Breakfast / View Exhibits

8:00-8:30 am Seiji Lectureship: Introduction: Giuseppe Prota, President IFPCS

#35 Richard A King: "Albinism as a Model System of Melanin Regulation"

Symposium III: Melanoma Research: Basic and Applied

Co-Chairs: Frank Meyskens, Eberhard Paul, Kowichi Jimbow

8:30-9:00 am Keynote Speaker

#36 Alistair Cochran: "Predictions of Outcomes for Patients with Cutaneous Melanoma"

9:00-10:30 am Invited and Competitive Abstract Speakers

#37 John Fruehauf: "Selective cytotoxic action of BSO on human melanoma"

#38 Yutaka Mishima: "Selective eradication and diagnosis of malignant melanoma; melanogenesis investigations leading to novel neutron capture therapy"

#39 Eva M Link: "211At-methylene blue for treatment of disseminated melanoma"

#40 Juichiro Nakayama: "Different pattern of modulation between cytokine-induced and hypertherma-induced ICAM-1 expression in human malignant melanoma cell lines in vitro"

#41 Mei-Yu Hsu: "The role of e-cadherin in keratinocyte-melanocyte cross-talk"

10:30-11:00 am Break

11:00-12:30 pm Workshop F: Control of Melanogenesis

Chair and Overview, John M Pawelek, "DHICA polymerization and the silver phenotype",

Co-Chairs: Katsuhiko Tsukamoto, Brian Weatherhead

Invited and Competitive Speakers

#42 Hirofumi Kondoh: "The role of TRPs (tyrosinase related proteins) in the control of eumelanogenesis"

#43 Francisco Solano: "Comparison and properties of TRPs from murine and human malignant melanocytes"

#44 Michele Miranda: "Melanogenesis, tyrosinase expression and reproductive differentiation in black and white truffles (ascomycotina)"

#45 Harish Mahalingam: "Interplay of signaling mechanisms regulating tyrosinase gene expression"

#46 Hua Chen: "Involvement of phosphatidylinositol 3-kinase activity in the sorting and transport of newly synthesized tyrosinase-related protein-1 in melanogenesis"

12:30-1:30 pm Simultaneous Business Meetings of Regional Societies

12:30-2:00 pm Lunch on your own

Symposium IV: Photobiology of Melanocytes: Etiology and Prevention

Co-Chairs: JP Cesarini, Masamitsu Ichihashi, Lisa Zeise

2:00-2:30 pm Keynote Speaker

#47 Nik Kollias

2:30-4:00 pm Invited and Competitive Abstract Speakers

#48 Yoko Funasaka: "The effect of ultraviolet B induced adult T cell leukemia-derived factor on survival and growth of human melanocytes"

#49 Frank L Meyskens Jr: "Expression of NF-kB/IkB/c-Rel in human melanocytes and melanoma cells: changes in association and dissociation"

#50 Mauro Picardo: "Alteration of antioxidants in normal melanocytes from patients with melanoma"

#51 Mayumi Fujita: "Activation of p53 is required for ultraviolet radiation-induced cell cycle arrest, apoptosis and BCL-2 regulation in melanoma cells"

#52 Ashok K Chakraborty: "Production and release of proopimelanocortin (POMC) derived peptides by human melanocytes and keratinocytes in culture: regulation by UVB"

4:00-7:00 pm Workshop G: The "Blues" Symposium

Chair: Joseph T Bagnara, Co-Chairs: Jean L Bolognia, Yoshiaki Hori

#53 Joseph T Bagnara: "Introduction and overview of blue pigmentation"

#54 Craig Bohren: "A brief tour of light scattering with a side trip into colorimetry Human Cerulodermas"

#55 Jean L Bolognia: "Blue nevi and Mongolian spots"

#56 Yoshiaki Hori: "The nevus of Ota and other nevus fuscocaeruleus"

#57 Ryozo Fujii: "The blue colors of fish"

#58 Philip J Fernandez: "Blue skin color in amphibians"

#59 Randall L Morrison: "Mechanisms of structural color production in the skin of reptiles and birds"

#60 Walter C Quevedo, Jr: "The blue colors of mammals"

4:00-7:00 pm Poster Viewing

7:00 pm Adjourn Free evening

Friday, November 1, 1996

7:00-8:00 am Continental Breakfast/View Exhibits

8:00-8:30 am Introduction: Vincent Hearing, past-President PASPCR

#61 Gelb Lectureship: Seth Orlow "The biogenesis of melanosomes"

Symposium V: Melanogenesis and Pigmentary Disorders

Co-Chairs: James Nordlund, Wiete Westerhof, Yoshiaki Hori

8:30-9:00 am Keynote Speaker

#62 Raymond E Boissy: "Melanogenesis and Pigmentary Disorders"

9:00-10:30 am Invited and Competitive Abstract Speakers

#63 Masako Mizoguchi: "Melanogenesis in acquired dermal melanocytosis"

#64 Richard Spritz: "Mapping and mutation analyses of the genes for Hermansky-Pudlak Syndrome and Chediak-Higashi Syndrome"

#65 James P Fryer: "Analysis of splice site mutations in individuals with OCA1 using illegitimate transcription as a source of tyrosinase RNA in lymphocytes"

#66 Vincent J Hearing: "Mutational analysis of copper-binding by human tyrosinase and differential binding of divalent metal cations by the tyrosinase-related proteins"

10:30-11:00 am Break

11:00-12:30 pm Workshop H: Biology and Biochemistry of Melanosomes

Chair and Overview: Yutaka Mishima, "Melanosomes as a specialized hysosomes - transfection of melanogenic genes into melanin-deficient pigment cells and fibroblasts",

Co-chairs: Seth Orlow, Jan Borovansky

Invited and Competitive Abstract Speakers

#67 Kowichi Jimbow: "Molecular biology of tyrosinase-related protein, assessment of biological role, biosynthesis and transport from TGN to pre-stage I melanosome through gene transfection"

#68 Keishi Araki: "Analysis of the role of small GTP binding protein RAB in intracellular melanosome transport"

#69 Chie Sakai: "Modulation of expression and activity of melanosomal proteins in murine melanocytes by agouti signal protein"

#70 John A Hammer: "The absence of a myosin V dependent transport system underlies in part the coat color defect in dilute mice"

#71 Paul F Gomez: "A small molecular weight, GTP-binding protein, rab-7, is involved in the transport of TRP-1 from TGN to melanosomes"

11:00-12:30 pm Posters and Discussion #3: Biophysics and Chemistry of Melanin

Patrick A Riley, Chair

11:00-12:00 pm Poster Viewing

12:00-12:30 pm Discussion

12:30 pm Adjourn Scientific Session

12:30-1:30 pm Simultaneous Business Meetings of Regional Societies

1:30-6:30 pm Break

6:30-7:30 pm Reception

7:30-midnight Banquet, Awards and Dancing

IFPCS Awards to Be Presented:

Myron Gordon Award - to Prof Jiro Matsumoto

Seiji Memorial Lecture Award - to Prof Richard A King

Raper Medal - recipient to be announced

Takeuchi Medal - recipient to be announced

IFPCS Special Awards:

to Prof Joseph T Bagnara, Founding Editor, Pigment Cell Research

to Prof Yoshiaki Hori, Chairman, International Symposium on Melanogenesis and Malignant Melanoma

to Prof Frank L Meyskens, Jr, Alistair J Cochran & Roger R Bowers, Chair and Co-Chairs, XVIth IPCC

Saturday, November 2, 1996

7:00-8:00 am Continental Breakfast/View Exhibits

8:00-8:30 am Presidential Address: Giuseppe Prota, President IFPCS

#72 "Pigment Cell Research: What Directions?"

Symposium VI: Comparative Developmental Biology of Pigment Cells

Co-Chairs: Roger Bowers, Masataka Obika, Dorothy Bennett

8:30-9:00 am Keynote Speaker

#73 Jiro Matsumoto: "Molecular Biology of Fish Pigmentation: Up-to-Date"

9:00-10:30 am Invited and Competitive Abstract Speakers

#74 Sally Frost-Mason: "From three pigment cell types to one. An evolutionary perspective of vertebrate chromatophore development"

#75 Dorothy Bennett: "Differential gene expression in immortal melanocytes, melanoblasts and melanoblast precursors"

#76 Bernard Wehrle-Haller: "Early melanocyte precursor migration is directed by localized steel factor"

#77 Mark Moody: "Enhancement of the xanthophore lineage in guanosine-treated axolotl neural crest cells in vitro"

#78 William Pavan: "Genetic regulation of melanocyte patterning"

10:30-11:00 am Break

11:00-12:30 pm Workshop I: Genetic Aspects of Albinism

Chair and Overview: Richard A King, Co-Chairs: Fritz Anders, Yasushi Tomita

Invited and Competitive Abstract Speakers

#79 Jun Matsunaga: "Sequence analysis of the human tyrosine promoter from a patient with tyrosinase-negative oculocutaneous albinism"

#80 Friedrich Beermann: "Regulation of tyrosinase expression in transgenic mice"

#81 Julie M Newton: "Molecular characterization of a mouse homolog for the human ocular albinism 1 (OA1) gene"

#82 William S Oetting: "Analysis of the P gene in individuals with tyrosinase positive oculocutaneous albinism (OCA2)"

Workshop J: Melanocytic Nevi: Clinical and Laboratory Investigations

Chair and Overview: Stan Pavel, “Melanocytic neve: clinical and laboratory investigation”, Co-Chairs: Shinji Shimada, Arthur R Rhodes

Invited and Competitive Abstract Speakers

#83 W Bergman: "The relationship of atypical nevi and multiple mole melanoma in the FAMMM syndrome"

#84 R Akasu: "Videomicroscopic features of melanocytic plantar nevi"

#85 Jerry O’Connell: "Chimeric nevi: collision tumors that are variants of combined nevus"

#86 Paolo Antonio: "The epiluminescence microscopy in the diagnosis of pigmented cutaneous lesions: the experience of National Cancer Institute of Naples, Italy"

#87 Zhao-lun Chen: "An immunohistoschemical study on the expression of p53 protein, c-erb-2, and PCNA in malignant and benign melanocytic lesions"

11:00-12:30 pm Posters and Discussion #4: Pigment Cell Development and Dysfunction:

Walter C Quevedo, Jr, PhD, Chair

11:00-12:00 pm Poster Viewing

12:00-12:30 pm Discussion

12:30-2:00 pm Lunch on your own

2:00-4:00 pm Educational Forum: "Living with the Sun"

4:00-6:00 pm Family Farewell Reception

Sunday, November 3, 1996

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This page was modified last on July 18, 1996.
For suggestions, please contact Vince Hearing at hearingv@dc37a.nci.nih.gov